This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior Director, R&D PMO & Innovation Excellence based in United States. This is a strategic leadership opportunity to shape how complex R&D, product development, transformation, and integration initiatives move from strategy to measurable business outcomes. You will lead enterprise portfolio governance, integrated planning, resource allocation, and program execution across a broad and highly cross-functional environment. The role combines disciplined PMO leadership with needs-driven innovation, helping teams prioritize investments and accelerate value delivery. You will partner closely with senior executives and leaders across R&D, Product, Commercial, Operations, Manufacturing, Supply Chain, Quality, Regulatory, Finance, IT, and other functions. As a senior change leader, you will establish scalable processes, decision frameworks, reporting mechanisms, and innovation practices that improve organizational effectiveness. You will also build and develop a high-performing PMO and innovation excellence team through coaching, reusable tools, communities of practice, and continuous improvement. This role is ideal for an accomplished portfolio and innovation leader who can bring clarity to complexity, align diverse stakeholders, and turn strategic priorities into disciplined execution.